Treating active rheumatoid arthritis with Janus kinase inhibitors
نویسندگان
چکیده
منابع مشابه
B-cell kinase inhibitors in rheumatoid arthritis
Introduction The pathogenesis of rheumatoid arthritis (RA) involves systemic dysregulation of T and B lymphocytes resulting in immune responses against self-antigens, and ultimately leading to downstream effects such as cartilage destruction, pannus formation, and bone erosion. Clinical evidence for the role of B cells in RA includes the effectiveness of rituximab, an antibody designed to deple...
متن کاملPromising new treatments for rheumatoid arthritis - the kinase inhibitors.
Three major advances over the last decade have impacted the way we treat rheumatoid arthritis; early and aggressive treatment, use of disease activity measures leading to treat to target, and availability of biologic agents. No oral biologic agents are available at this time but promising data is emerging for two drugs, tofacitinib and fostamatinib, inhibitors of JAK and Syk kinases, respective...
متن کاملTyrosine Kinase Inhibitors for the Treatment of Rheumatoid Arthritis
Tyrosine kinases (TK) are enzymes capable of transferring phosphate groups to tyrosine residues in cytoplasmic proteins or the intracellular domains of transmembrane receptors. TK play critical roles in diverse biological functions including cellular processes such as adhesion, motility, proliferation, cell cycle control, cell death, as well as biological functions at the whole-organism level s...
متن کاملPatients with Active Rheumatoid Arthritis Have Lower Frequency of nTregs in Peripheral Blood
Background: Patients with rheumatoid arthritis (RA) suffer from wide ranges of autoimmune reactions in joints. The mechanism of which is generally unknown and maybe associated with Treg deregulation. Objective: To compare the frequency of nTregs in peripheral blood of patients with active rheumatoid disease with healthy individuals. Methods: Twenty five newly diagnosed patients with active RA d...
متن کاملAdvances in the Inhibitors of Janus Kinase
In recent years, for the lesion site, studies at the molecular level of drugs targeting protein molecules has been a major research method for exploiting new, high-efficiency drugs with low toxicity [1]. Janus kinases (JAKs) are important signal transducers of many cytokines, growth factors and interferon. In recent years, it has been found in cancer cells and cells transfected with oncogenes t...
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ژورنال
عنوان ژورنال: The Lancet
سال: 2017
ISSN: 0140-6736
DOI: 10.1016/s0140-6736(17)31659-8